Table 3.
Univariate and multivariate analysis of recurrence-free survival (RFS) in Gastric cancer (GC) patients underwent ESD/ gastrectomy in training cohort
| Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|
| P | HR | 95% confidence interval | P | HR | 95% confidence interval | |
|
Gender male/female |
0.176 | 1.129 | 0.940–1.357 | |||
|
Age > 60 y/≤60 y |
0.062 | 1.201 | 0.989–1.458 | |||
|
ASA II/I |
0.482 | 1.069 | 0.848–1.345 | |||
|
ECOG PS 1/0 |
0.347 | 0.892 | 0.692–1.147 | |||
|
Family history of gastric cancer Yes/No |
0.079 | 1.256 | 0.971–1.623 | |||
|
Tumor size > 2.0 cm/≤2.0 cm |
0.019 | 1.395 | 1.063–1.832 | 0.091 | 1.241 | 0.927–1.663 |
|
Differentiation Poorly/ high + Moderately |
0.029 | 1.342 | 1.032–1.746 | 0.037 | 1.286 | 1.017–1.624 |
|
Vascular invasion Yes/No |
< 0.001 | 2.014 | 1.548–2.616 | < 0.001 | 1.852 | 1.381–2.454 |
|
P53 Yes/No |
0.006 | 1.546 | 1.133–2.114 | 0.023 | 1.389 | 1.047–1.844 |
|
Ki-67 ≥ 50%/<50% |
0.301 | 1.153 | 0.896–1.484 | |||
|
Tumor infiltration Submucosa/ Mucosa |
0.018 | 1.405 | 1.065–1.856 | 0.052 | 1.224 | 0.999–1.501 |
|
MSI status MSI-high/ (MSS/MSI-low) |
0.485 | 1.114 | 0.844–1.472 | |||
|
Treatment method ESD/ gastrectomy |
0.102 | 1.200 | 0.973–1.479 | |||
ESD: Endoscopic Submucosal Dissection; ASA:American Society of Anesthesiologists;ECOG:Eastern Cooperative Oncology Group; CTC: Circulating Tumor Cells
TNM stages are according to AJCC 8th edition