Table 2.
Top pathways from KEGG, WikiPathways, Reactome and BioCarta databases and their corresponding P-values and genes for common differentially expressed genes
| Databases | Pathways | P-value | Genes |
|---|---|---|---|
| KEGG | Mismatch repair | 0.015985227 | PCNA |
| Base excision repair | 0.022861069 | PCNA | |
| DNA replication | 0.024915106 | PCNA | |
| Cell cycle | 0.003304756 | RB1;PCNA | |
| Bladder cancer | 0.028329595 | RB1 | |
| Ferroptosis | 0.028329595 | FTH1 | |
| Nucleotide excision repair | 0.032412327 | PCNA | |
| Hepatitis B | 0.005566263 | RB1;PCNA | |
| Fanconi anemia pathway | 0.03715538 | UBE2T | |
| Kaposi sarcoma-associated herpesvirus infection | 0.007811021 | RB1;HIF1A | |
| WikiPathways | LncRNA-mediated mechanisms of therapeutic resistance WP3672 | 0.00419312 | HIF1A |
| Pilocytic astrocytoma WP2253 | 0.00419312 | NF1 | |
| MicroRNA for Targeting Cancer Growth and Vascularization in Glioblastoma WP3593 | 0.004890388 | HIF1A | |
| HIF1A and PPARG regulation of glycolysis WP2456 | 0.005587202 | HIF1A | |
| Glycolysis in senescence WP5049 | 0.007674931 | RB1 | |
| NAD metabolism, sirtuins and aging WP3630 | 0.007674931 | HIF1A | |
| Iron metabolism in placenta WP2007 | 0.008369936 | FTH1 | |
| Aryl Hydrocarbon Receptor Netpath WP2586 | 0.000462719 | RB1;NF1 | |
| H19 action Rb-E2F1 signaling and CDK-Beta-catenin activity WP3969 | 0.009758591 | RB1 | |
| ID signaling pathway WP53 | 0.01114544 | RB1 | |
| Reactome | PTK6 Expression R-HSA-8849473 | 0.003495399 | HIF1A |
| SARS-CoV-1 Genome Replication And Transcription R-HSA-9679514 | 0.003495399 | RB1 | |
| SARS-CoV-2 Genome Replication And Transcription R-HSA-9694682 | 0.003495399 | RB1 | |
| NOSTRIN Mediated eNOS Trafficking R-HSA-203641 | 0.003495399 | CAV1 | |
| PTK6 Promotes HIF1A Stabilization R-HSA-8857538 | 0.00419312 | HIF1A | |
| RAS Signaling Downstream Of NF1 Loss-Of-Function Variants R-HSA-6802953 | 0.00419312 | NF1 | |
| CD163 Mediating An Anti-Inflammatory Response R-HSA-9662834 | 0.006283564 | PLK2 | |
| Condensation Of Prometaphase Chromosomes R-HSA-2514853 | 0.006979474 | NCAPD2 | |
| STAT3 Nuclear Events Downstream Of ALK Signaling R-HSA-9701898 | 0.006979474 | HIF1A | |
| eNOS Activation R-HSA-203615 | 0.007674931 | CAV1 | |
| BioCarta | p53 Signaling Pathway Homo sapiens h p53Pathway | 3.53E-05 | RB1;PCNA |
| Overview of telomerase RNA component gene hTerc Transcriptional Regulation Homo sapiens h tercPathway | 0.004890388 | RB1 | |
| VEGF, Hypoxia, and Angiogenesis Homo sapiens h vegfPathway | 0.000195723 | CAV1;HIF1A | |
| BTG family proteins and cell cycle regulation Homo sapiens h btg2Pathway | 0.006283564 | RB1 | |
| Cyclin E Destruction Pathway Homo sapiens h fbw7Pathway | 0.006283564 | RB1 | |
| E2F1 Destruction Pathway Homo sapiens h skp2e2fPathway | 0.006979474 | RB1 | |
| Regulation of transcriptional activity by PML Homo sapiens h pmlPathway | 0.007674931 | RB1 | |
| Regulation of p27 Phosphorylation during Cell Cycle Progression Homo sapiens h p27Pathway | 0.009064489 | RB1 | |
| RB Tumor Suppressor/Checkpoint Signaling in response to DNA damage Homo sapiens h rbPathway | 0.009064489 | RB1 | |
| Erythropoietin mediated neuroprotection through NF-kB Homo sapiens h eponfkbPathway | 0.009064489 | HIF1A |