Table 4.
Model effect estimates, sensitivity analyses
| Modela | Effect estimateb (95% CI) |
P value |
|---|---|---|
| Duration of hypotension (MAP < 65) | ||
| Crude | − 0.31 (− 0.39 to − 0.22) | < 0.001 |
| Propensity adjusted | − 0.33 (− 0.41 to − 0.24) | < 0.001 |
| Inverse probability of treatment weighting | − 0.35 (− 0.43 to − 0.27) | < 0.001 |
| Multiple imputation propensity adjustment | − 0.33 (− 0.41 to − 0.25) | < 0.001 |
| Post hoc sensitivity–adjusted for sex | − 0.35 (− 0.32 to − 0.27) | < 0.001 |
| Acute kidney injury | ||
| Crude | 0.93 (0.67 to 1.27) | 0.674 |
| Propensity adjusted | 0.83 (0.60 to 1.14) | 0.270 |
| Inverse probability of treatment weighting | 0.91 (0.63 to 1.33) | 0.637 |
| Multiple imputation propensity adjustment | 0.88 (0.65 to 1.20) | 0.432 |
| Post hoc sensitivity–adjusted for sex | 0.90 (0.61 to 1.31) | 0.571 |
CI confidence interval: MAP mean arterial blood pressure
aAll models are adjusting for time in which blood pressure is measured (i.e., time at risk)
bEffect estimates for hypotension are reported as exponentiated beta coefficients (i.e., ratio of expected geometric means), whereas effect estimates for acute kidney injury are reported as odds ratios