Table 3.
Univariate and multivariate analyses of prognostic factors for recurrence-free survival of TSCC
| Variables | Univariate analysis | Multivariate analysis | |||||
|---|---|---|---|---|---|---|---|
| HR | (95% CI) | P value | HR | (95% CI) | P value | ||
| Age: ≤67 years vs. > 67 years | 0.97 | (0.40–2.32) | 0.936 | ||||
| Sex: female vs. male | 0.59 | (0.25–1.43) | 0.242 | ||||
| Pathological T stage: T1/2 vs. T3/4a | 2.14 | (0.89–5.17) | 0.091 | ||||
| Metastasis of cervical lymph node: Absent vs. Present | 3.31 | (1.36–8.05) | 0.008 | 3.29 | (1.23–8.76) | 0.017 | |
| TNM stage: I-II vs. III-IV | 2.46 | (0.98–6.19) | 0.056 | ||||
| Tumor size(mm): ≤25 mm vs. > 25 mm | 2.07 | (0.84–5.06) | 0.112 | ||||
| Depth of Invasion(mm): ≤8 mm vs. > 8 mm | 2.33 | (0.93–5.86) | 0.072 | ||||
| Histological differentiation: Mod/Poor vs. Well | 0.51 | (0.21–1.23) | 0.134 | ||||
| Mode of invasion (YK classification): 1–3 vs. 4 C/4D | 1.79 | (0.73–4.40) | 0.201 | ||||
| Visual type of proliferation: Superficial/Exophytic vs. Endophytic | 0.93 | (0.37–2.34) | 0.880 | ||||
| Venous invasion: Negative vs. Positive | 1.73 | (0.72–4.16) | 0.221 | ||||
| Perineural invasion: Negative vs. Positive | 2.99 | (1.19–7.52) | 0.020 | 2.22 | (0.86–5.77) | 0.101 | |
| Lymph duct invasion: Negative vs. Positive | 1.72 | (0.63–4.74) | 0.293 | ||||
| IgG4 expression: Low vs. High | 0.33 | (0.13–0.85) | 0.022 | 0.22 | (0.07–0.62) | 0.005 | |
| Foxp3 expression: Low vs. High | 0.31 | (0.12–0.82) | 0.018 | 0.27 | (0.10–0.74) | 0.011 | |