Table 1.
Rheumatoid factor and anti-citrullinated protein antibodies in the studied groups
| RA (n = 20) |
FDRs (n = 25) |
Controls (n = 10) |
P | ||
|---|---|---|---|---|---|
| RF (< 15.9 IU/ml) | |||||
| Negative No. (%) | 2 (10.0%) | 25 (100.0%) | 10 (100.0%) | < 0.001* | |
| Positive No. (%) | 18 (90.0%) | 0 (0.0%) | 0 (0.0%) | ||
| Min. – Max. | 9.0–697.0 | 4.80–12.70 | 8.20–11.75 | < 0.001* | |
| Mean ± SD. | 133.28 ± 176.38 | 9.21 ± 1.9 | 9.92 ± 1.19 | ||
| Median | 68.40 | 9.19 | 9.40 | ||
| Significance between groups | p1 < 0.001*, p2 < 0.001*, p3 = 0.358 | ||||
| ACPA(< 20 U/ml) | |||||
| Negative No. (%) | 3(15%) | 25(100%) | 10(100%) | < 0.001* | |
| Positive No. (%) | 17(85%) | 0 (0%) | 0 (0%) | ||
| Min. – Max. | 7.0–915.0 | 5.0–17.60 | 6.50–10.70 | < 0.001* | |
| Mean ± SD. | 226.83 ± 266.19 | 11.06 ± 3.43 | 9.53 ± 1.34 | ||
| Median | 107.0 | 11.20 | 9.75 | ||
| Significance between groups | p1 < 0.001*, p2 < 0.001*, p3 = 0.131 | ||||
p value for Kruskal Wallis test for comparing between the different groups; Significance between groups was done using Mann Whitney test; p1: p value for comparing between RA patients and FDRs; p2: p value for comparing between RA patients and controls; p3: p value for comparing between FDRs and controls; *: Statistically significant at p ≤ 0.05
RA: rheumatoid arthritis; FDRs: first degree relatives; RF: rheumatoid factor; ACPA: anti-citrullinated protein antibodies