Table 4.
Relation between articular manifestations and different parameters in first degree relatives (n = 25)
| Asymptomatic FDRs (n = 17) |
FDRs with arthralgia (n = 8) |
P | |
|---|---|---|---|
| No. (%) | No. (%) | ||
| ESR 1st hr(10 mm/hr) | |||
| Min. – Max. | 5.0–20.0 | 9.0–45.0 | 0.003* |
| Mean ± SD. | 9.82 ± 4.13 | 27.88 ± 11.22 | |
| Median | 8.0 | 27.50 | |
| CRP (< 3 mg/L) | |||
| Min. – Max. | 0.82–13.0 | 2.88–19.0 | 0.003* |
| Mean ± SD. | 3.93 ± 3.58 | 10.36 ± 5.21 | |
| Median | 2.78 | 9.87 | |
| RF (< 15.9 IU/ml) | |||
| Negative | 17 (100) | 8 (100) | - |
| Positive | 0 (0) | 0 (0) | |
| Min. – Max. | 4.90–12.70 | 4.80–12.50 | 0.137 |
| Mean ± SD. | 8.55 ± 2.49 | 9.52 ± 1.54 | |
| Median | 9.18 | 9.19 | |
| ACPA (< 20 U/ml) | |||
| Negative | 17 (100) | 8 (100) | - |
| Positive | 0 (0) | 0 (0) | |
| Min. – Max. | 7.40–17.0 | 5.0–17.60 | 0.560 |
| Mean ± SD. | 10.44 ± 3.31 | 11.35 ± 3.55 | |
| Median | 9.80 | 11.20 | |
| Serum OPN (ng/ml) | |||
| Min. – Max. | 1.0–2.40 | 0.90–5.80 | 0.620 |
| Mean ± SD. | 1.70 ± 0.55 | 2.09 ± 1.19 | |
| Median | 1.60 | 1.80 | |
| Serum OPG (pg/ml) | |||
| Min. – Max. | 0.0–27.20 | 0.0–334.10 | 0.314 |
| Mean ± SD. | 8.44 ± 9.67 | 51.55 ± 114.68 | |
| Median | 1.50 | 14.25 | |
p: p values for Mann Whitney test for comparing between the two groups; *: Statistically significant at p ≤ 0.05
FDRs: first degree relatives; ESR: erythrocyte sedimentation rate; CRP: c-reactive protein; OPN: Osteopontin; OPG: Osteoprotegerin