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. 2024 Mar 4;16(1):2323231. doi: 10.1080/19490976.2024.2323231

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© 2024 The Author(s). Published with license by Taylor & Francis Group, LLC.

This is an Open Access article distributed under the terms of the Creative Commons Attribution-NonCommercial License (http://creativecommons.org/licenses/by-nc/4.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The terms on which this article has been published allow the posting of the Accepted Manuscript in a repository by the author(s) or with their consent.

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Figure 4. — Changes in fecal bile acid composition in pediatric IBD. (a) PCoA of IBD-Act, IBD-Rem, and HC based on Bray-Curtis dissimilarity metrics, with statistical significance and variance of dissimilarity data assessed using ANOSIM. (b) Heatmap of Spearman’s correlation between differential fecal bile acids and clinical indicators; *p < .05, **p < .01, ***p < .001. primary and secondary bile acids are depicted by orange and green bars, respectively. (c) Integrated network of IBD severity-related microbial species and fecal bile acids using the group attributes layout method of cytoscape. The size of the edge indicates the degree of Spearman’s correlation. Direct correlations are highlighted as red edges, and inverse correlations as blue edges, with a cutoff of p < .05 and r > 0.4 or r<–0.4. Bile acid categories that could not be accurately classified are not listed.