Figure 1.

Use of glycolysis, the TCA cycle and oxidative phosphorylation during neuronal development. A, Use of glycolysis, the TCA cycle and oxidative phosphorylation in neuronal stem cells. AA, amino acids. B, Use of glycolysis, the TCA cycle and oxidative phosphorylation in differentiated neurons. C, Regulation of glycolysis and oxidative phosphorylation during neuronal differentiation in Drosophila. D, The systemic metabolic switch at the onset of the pupal stage in Drosophila. The VCO₂/VO₂ ratio enables conclusions about metabolic fuel usage. E, Regulation of energy metabolism during neurite pruning, likely in response to the metabolic switch depicted in (D). 20E, 20-hydroxy-ecdysone; VCO₂, CO₂ release as measure of metabolic rate; VO₂, oxygen consumption.