Table 2.
MRI volumetric parameters of healthy controls, all MS patients and RRMS- and SPMS-subgroups.
| HC | MS | HC vs. MS, p-value | RRMS | SPMS | RRMS versus SPMS | |
|---|---|---|---|---|---|---|
| Brain volume (PF) | 0.855 (0.036) | 0.828 (0.046) | <0.001 | 0.834 (0.043) | 0.810 (0.050) | 0.034 |
| NAWM volume (PF) | 0.35 (0.025) | 0.33 (0.036) | <0.001 | 0.33 (0.026) | 0.32 (0.053) | 0.035 |
| Cortical GM volume (PF) | 0.33 (0.022) | 0.31 (0.025) | <0.001 | 0.32 (0.021) | 0.30 (0.031) | 0.003 |
| Thalamus volume (PF) | 0.011 (0.0011) | 0.010 (0.0013) | <0.001 | 0.010 (0.0011) | 0.010 (0.0017) | 0.059 |
| T1 lesion load (cm3), median (IQR) | – | 2.95 (1.28–8.58) | – | 2.32 (1.11–4.17) | 11.2 (6.95–23.2) | <0.001 |
| T2 lesion load (cm3), median (IQR) | – | 6.01 (2.88–17.6) | – | 4.14 (2.60–10.9) | 18.5 (11.1–34.6) | <0.001 |
Values are mean (SD) unless otherwise stated. For group comparisons, p-values are from Wilcoxon rank-sum test. Significant p-values are bolded. GM, gray matter; HC, healthy control; IQR, interquartile range; MS, multiple sclerosis; NAWM, normal-appearing white matter; PF, parenchymal fraction; RRMS, relapsing remitting MS; SPMS, secondary progressive MS.