Table 1.

Relationship of advanced paternal age on semen parameters in the 2015 meta-analysis (in bold) and subsequently published studies.

Year	Authors	Study design	# patients	Volume	Count	Concentration	Motility	Morphology	Vitality	DFI
2015	Johnson et al.(17)	Meta-analysis	93,839	↓	↓	–	↓	↓	N/A	↑
2016	Yeste et al.(18)	Case-control study	71	N/A	N/A	N/A	↓	N/A	N/A	N/A
2018	Veron et al.(19)	Cross sectional study	11,706	↓	↓	–	↓	–	↓	N/A
2018	Lai et al.(20)	Retrospective cohort study	3,549	↓	–	↑	↓	–	N/A	N/A
2019	Colasante et al.(6)	Retrospective cohort study	3,124	↓	–	–	↓	–	N/A	↑
2019	Albani et al.(21)	Prospective cohort study	89	N/A	N/A	N/A	N/A	N/A	N/A	↑
2019	Rosiak-Gill(22)	Cross sectional study	1,124	↓	–	–	–	↓	N/A	↑
2019	Vinnakota et al.(23)	Cross sectional study	1,316	N/A	N/A	N/A	N/A	N/A	N/A	↑
2020	Pino et al.(9)	Cross sectional study	2,681	↓	↓	↓	↓	–	N/A	↑
2020	Guo et al.(24)	Cross sectional study	654	N/A	N/A	N/A	N/A	N/A	N/A	↑
2020	Lu et al.(25)	Cross sectional study	1,790	N/A	N/A	N/A	N/A	N/A	N/A	↑
2020	Evenson et al.(26)	Case-control study	25,445	N/A	N/A	N/A	N/A	N/A	N/A	↑
2020	Salmon-Divon et al.(27)	Cross sectional study	12,188	↓	↓	–	↓	–	N/A	N/A
2021	Zhang et al.(28)	Cross sectional study	5,114	N/A	N/A	N/A	N/A	N/A	N/A	↑
2021	Collodel et al.(29)	Cross sectional study	1,294	–	N/A	↓	↓	N/A	↓	N/A
2021	Gao et al.(30)	Cross sectional study	18,441	↓	↓	↑	↓	–	N/A	↑
2021	Rubes et al.(31)	Cross sectional study	150	N/A	N/A	N/A	N/A	N/A	↓	↑
2021	Demirkol et al.(8)	Cross sectional study	500	–	–	–	↓	↓	↓	N/A

↑ = increase with age; ↓ = decrease with age; ─ = no correlation; N/A = not assessed.