Table 1 |. Results for the 27 genome-wide significant index variants identified in the GWAS meta-analysis of 38,691 individuals with ADHD and 186,843 controls.

The location (chromosome (chr)) base position (bp) in hg19), alleles (A1 and A2), frequency (Freq.) of A1 in cases and controls, odds ratio (OR) of the effect with respect to A1, standard error (s.e.) and association P-values (two-sided) from inverse-variance weighted fixed effects model of the index variants are given. “Novel” indicates if the locus is a new ADHD risk locus i.e., not identified in ADHD2019 (ref. ¹⁴). Nearby genes located within 50 kb from index variants are listed (for a list of mapped genes based on other criteria see Supplementary Table 8).

Genomic locus	chr	bp	rs ID	A1	A2	Nearby genes	Freq. cases	Freq. controls	OR	s.e.	P-value	Novel
1	1	44076469	rs549845	G	A	PTPRF, KDM4A	0.321	0.326	1.082	0.01	9.03E-15	no
2	2	145714354	rs1438898	A	C		0.762	0.769	1.065	0.01	4.88E-09	yes
3	3	20724204	rs2886697	G	A		0.634	0.643	1.061	0.01	7.90E-10	no
4	3	43691501	rs9877066	G	A	SNRK, ANO10, ABHD5	0.944	0.951	0.888	0.02	6.60E-09	yes
5	3	49916710	rs7613360	C	T	TRAIP, CAMKV, MST1R, CTD-2330K9.3, MON1A	0.598	0.614	0.948	0.01	3.18E-08	yes
6	3	51884072	rs2311059	G	A	IQCF3, IQCF2, IQCF5, IQCF1	0.314	0.308	0.944	0.01	3.16E-08	yes
7	3	71499401	rs17718444	C	T	FOXP1	0.695	0.660	1.063	0.01	2.87E-09	yes
8	3	87015142	rs114142727	C	G	VGLL3	0.988	0.988	1.285	0.04	5.13E-10	yes
9	4	112217523	rs17576773	C	T		0.888	0.880	1.101	0.02	1.63E-10	yes
10	4	147099654	rs6537401	G	A	LSM6, RP11-6L6.2, SLC10A7	0.660	0.655	0.945	0.01	1.40E-08	yes
11	5	87854395	rs4916723	A	C		0.553	0.573	0.918	0.01	9.48E-15	no
12	5	103964585	rs77960	G	A		0.665	0.682	0.929	0.01	2.46E-13	yes
13	5	144474779	rs10875612	C	T		0.483	0.470	0.947	0.01	5.62E-09	yes
14	6	70858701	rs2025286	A	C	COL19A1	0.553	0.550	0.947	0.01	4.00E-09	yes
15	7	67685754	rs73145587	A	T		0.910	0.901	1.107	0.02	3.67E-08	yes
16	7	114158954	rs9969232	G	A	FOXP2	0.344	0.382	0.934	0.01	9.98E-12	no
17	8	93277087	rs7844069	T	G		0.428	0.399	1.057	0.01	6.74E-09	yes
18	8	145802447	rs4925811	T	G	C8orf82, ARHGAP39	0.515	0.531	0.944	0.01	8.30E-09	yes
19	10	8784773	rs11255890	C	A		0.389	0.401	1.054	0.01	4.14E-08	yes
20	10	106453832	rs11596214	G	A	SORCS3	0.597	0.569	1.054	0.01	3.17E-08	no
21	11	28602173	rs2582895	C	A	METTL15	0.634	0.618	1.075	0.01	4.09E-14	yes
22	12	89771903	rs704061	T	C	DUSP6, POC1B	0.554	0.560	0.946	0.01	2.30E-09	no
23	14	98690923	rs76284431	T	A		0.847	0.842	0.922	0.01	1.19E-09	yes
24	16	61966703	rs1162202	C	T	CDH8	0.630	0.606	1.063	0.01	1.92E-09	yes
25	18	5871800	rs76857496	C	A	TMEM200C	0.870	0.859	1.083	0.01	1.24E-08	yes
26	18	50625779	rs7506904	G	A	DCC	0.343	0.372	0.946	0.01	1.24E-08	yes
27	20	21250843	rs6082363	T	C	XRN2, NKX2-4	0.296	0.291	1.073	0.01	4.38E-12	yes