Fig. 4.

Patient-reported outcomes from baseline to 26 months of active berotralstat treatment for patients who entered Part 2 of APeX-J (n = 17). Mean (SEM) AE-QoL and TSQM scores for the All 150 mg group (A. and C.) and the All 110 to 150 mg group (B. and D.). Baseline values represent values on Day 1 before study drug administration. For TSQM, baseline values are based on the patient's reflection of the last treatment received. For patients who received berotralstat following placebo, months are adjusted according to the date of the first berotralstat dose. The black dotted line represents the MCID for the AE-QoL Total score. AE-QoL, Angioedema Quality of Life Questionnaire; BL, baseline; MCID, minimal clinically important difference; SEM, standard error of the mean; TSQM, Treatment Satisfaction Questionnaire for Medication