Table 1.

List of datasets used in this work.

Contrast	Cohort size	Reference	Organism
MASH F2 vs. MASLD	MASH = 153 MASLD = 53	64	Human
MASH F3 vs. MASLD
MASH F3 vs. MASH F0/1
MASH F4 vs. MASLD
MASH F4 vs. MASH F0/1
MASLD vs. CTRL	MASLD = 27 MASH = 25 CTRL = 39	65
MASH vs. CTRL (1)
MASLD stage 4 vs. CTRL	MASLD = 72 CTRL = 6	66
MASLD stage 5 vs. CTRL
MASLD stage 6 vs. CTRL
MASH vs. CTRL (2)	MASH = 16 CTRL = 14	42
HFD 30 vs. CTRL	HFD = 5 CTRL = 5	65	Mouse
MCD 8 vs. CTRL	MCD = 10 CTRL = 5
HFD+STZ 18 vs. CTRL	HFD+STZ = 5 CTRL = 4
WD vs. CTRL	WD = 5 CTRL = 5
APAP vs. CTRL	APAP = 44 CTRL = 5	66
CCl4 vs. CTRL (Acute)	CCl4 = 41 CTRL = 5
CCl4 vs. CTRL (Chronic)	CCl4 = 18 CTRL = 18
TM vs. CTRL	TM = 4 CTRL = 3
MASH vs. CTRL (1)	MASH = 9 CTRL = 4	68
MASH vs. CTRL (2)	MASH = 3 CTRL = 3	67
CYP51 LKO vs. CTRL	CYP51 = 3 CTRL = 3	69
GLMP KO vs. CTRL	GLMP = 4 CTRL = 4
IKBKG LKO vs. CTRL	IKBKG = 3 CTRL = 3
RBPJ LKO vs. CTRL	RBPJ = 3 CTRL = 4
WD+CCl4 (MASH) vs. CTRL	MASH = 17 CTRL = 9	Present study

Numbers after diet (HFD 30, MCD 8) correspond to number of weeks. MASLD stages 4–6 correspond to NAFLD activity score (NAS).

MASLD metabolic dysfunction-associated steatotic liver disease, MASH metabolic dysfunction-associated steatohepatitis, CTRL control, SHH sonic hedgehog, HFD high-fat diet, MCD methionine- and choline-deficient diet, STZ streptozocin, WD western diet, APAP acetaminophen, CCl4 carbon tetrachloride, TM tunicamycin, KO knockout, LKO liver knockout, CYP51 cytochrome P450 lanosterol 14α-demethylase, GLMP glycosylated lysosomal membrane protein, IKBKG inhibitor of kappa B kinase gamma, RBPJ recombination signal binding protein for immunoglobulin kappa J region.