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. 2023 Nov 17;70(3):165–177. doi: 10.1165/rcmb.2023-0147OC

Figure 2.

Figure 2.

CDH1 gene expression correlates with the expression of ten-eleven translocase dioxygenase (TET1). (A) Correlation of CDH1 gene expression with TET1 in human epithelial cells by Spearman rank correlation analysis (n = 5). (B–E) Gene expressions of (B) CDH1, (C) TET1, (D) TET2, and (E) TET3 in the cigarette-smoking (CS)–exposed normal epithelial cells (n = 6–7). (F) Gene expression of CDH1 in the 16HBE cell line with TET1 knockdown (n = 3). Top: lentivirus transduction efficiency indicated as GFP-tagged fluorescence, 10×. Scale bars, 100 μm. Bottom: CDH1 expression decreases with knockdown of TET1. Error bars represent SEM. Statistics were determined by using Mann-Whitney test in (B–E) and an ordinary one-way ANOVA with Sidak’s multiple comparison test in (F), with P < 0.05 considered statistically significant. Scale bars, 100 μm.