Table 13.

Frequencies of micronucleated polychromatic erythrocytes and polychromatic erythrocytes in micronucleus test.

Test substance	Route	Dose (mg/kg)	Hour after administration	Animal ID	PCE	NCE	PCE/(PCE + NCE)	MNPCE/4000PCE
Water for injection	P.O	0	24	1101	256	244	0.512	0
				1102	250	250	0.500	1
				1103	234	266	0.468	1
				1104	228	272	0.456	3
				1105	265	235	0.530	0
				Mean	–	–	0.493	1
				S.D	–	–	0.031	1.22
MCT Oil	P.O	0	24	1201	247	253	0.494	0
				1202	280	220	0.560	0
				1203	260	240	0.520	0
				1204	247	253	0.494	2
				1205	247	253	0.494	0
				Mean	–	–	0.512	1
				S.D	–	–	0.029	0.60
MK-7	P.O	0	24	1301	216	284	0.432	0
				1302	250	250	0.500	30
				1303	248	252	0.496	0
				1304	260	240	0.520	0
				1305	278	222	0.556	1
				Mean	–		0.501	0.8
				S.D			0.045	1.30
	P.O	0	24	1401	249	251	0.498	1
				1402	284	216	0.568	1
				1403	275	225	0.550	4
				1404	248	252	0.496	1
				1405	293	207	0.586	0
				Mean	–	–	0.540	1.4
				S.D	–	–	0.041	1.52
	P.O	0	24	1501	243	257	0.486	0
				1502	223	277	0.446	1
				1503	248	252	0.496	2
				1504	238	262	0.476	1
				1505	265	214	0.553	0
				Mean	–	–	0.491	0.8
				S.D	–	–	0.047	0.84
MMC	I.P	0	24	1601	261	239	0.522	60
				1602	242	258	0.484	62
				1603	286	214	0.572	90
				1604	277	223	0.554	74
				1605	263	237	0.526	83
				Mean	–	–	0.532	73.8
				S.D	–	–	0.034	13.01

I.P. intraperitoneal, MCT medium chain triglyceride (vehicle control), MMC mitomycin C, MNPCE micronucleated polychromatic erythrocyte, NCE normochromatic erythrocyte, PCE polychromatic erythrocyte, P.O. per Os (oral gavase), S.D. standard deviation.

*Significantly different from negative control by Fisher's extract test (p < 0.05).