FIG. 2.

The Eed-interacting clones encode the N-terminal part of Ezh2 protein, a mammalian homolog of the Drosophila E(z) protein. The cDNA inserts from the positive clones were sequenced, and a search for sequence similarity in a database was carried out. All of the clones matched the N-terminal part of the Ezh2 protein. The alignment of the shortest clone with different members of the E(z) protein family is shown. DmE(z), D. melanogaster E(z) protein (20); mEnx1, mouse Enx1 protein (16); HsEzh2, human Ezh2 protein (6); HsEzh1, human Ezh1 protein (1). Only N-terminal parts of the proteins are shown. Identical positions are shaded.