Table 1.
A chronicle of technologically key advancement in epileptic neural circuits research
| Year | Technique | Key advancement |
|---|---|---|
| 1846 | Electrophysiology | Neural action potentials first recording |
| 1911 | Chemogenetics | Initial chemogenetic approach conceptualization |
| Early 1920s | Electrophysiology | Oscilloscope bioelectric recording |
| 1970s | Optogenetics | Microbial opsins discovery and characterization |
| Calcium Imaging | Inauguration of fluorescent calcium imaging | |
| 1980s | Viral Tracing | Retrograde transsynaptic tracing demonstration |
| Viral Tracing | Development of attenuated PRV | |
| 1998 | Chemogenetics | GPCR-based DREADDs engineering |
| 2005 | Optogenetics | Microbial opsins-mediated rapid neural activation |
| 2006 | Optogenetics | The advent of the term "optogenetics" |
| 2007 | Optogenetics | Opsins-enabled behavioral modulation |
| Chemogenetics | Widespread adoption of DREADDs | |
| Chemogenetics | Ion channels methods inception | |
| In vivo microdialysis | Neurochemical monitoring in awake animal models | |
| 2009 | Optogenetics | Channelrhodopsin kinetics customization |
| 2010s | Viral Tracing | Enhancing utility via genetically modified VSV/HSV |
| Fiber Photometry | Optical fibers calcium indicators recording | |
| Recent years | Viral Tracing | Rabies virus modifications for function mapping |
| Electrophysiology | Non-invasive cellular microelectrodes |