Table 3.

Calcium imaging in the studies of neural circuits in epilepsy

Types of epilepsy	Animal models	Methods inducing epilepsy	Related neural circuits	References
TLE	Male adult wild-type Swiss mice and GAD67-Cre mice		Modified inhibitory circuitry in CA1 neural circuit	Muldoon et al. (2015)
Post-traumatic epilepsy	Model of post-traumatic epilepsy in mice	Organotypic hippocampal slice culture	Changes inducing pathology among large populations of neurons	Lau et al. (2022)
Epilepsy	Larval zebrafish model	STXBP1 mutations	Spontaneous hyper-synchronized neuronal ensembles	Liu et al. (2021)
Recurrent seizures	Scn1a ± mice	Targeted deletion of exon 1 of the Scn1a gene, PV-Cre mice	GABAergic interneurons	Tran et al. (2020)
Focal Epilepsies (Particularly TLE)	Adult mice (50 days, > 20 g)	Pilocarpine hydrochloride (335 mg/kg)	Ca2+-channel upregulation in hippocampal CA1 neurons	Kulbida et al. (2015)
MTLE	Mouse	4-AP	A transition among states in hippocampal CA1 neurons	Mulcahey et al. (2022)
Epilepsy	Larval zebrafish		Network dynamics and neuronal ensembles	Liu and Baraban (2019)
Epilepsy	Mouse model of GBM (3 months old)	Targeted knockout mutation of the MapT gene	Reproducible progression from hyperexcitability to convulsive seizures	Hatcher et al. (2020)
Epilepsy	Anesthetized and awake mice	4-AP (15 mM, 500 nl) or picrotoxin (10 mM, 500 nl)	GABAergic interneurons	Wenzel et al. (2017)
Epilepsy	Gabrg2 knockout zebrafish	Switching on the diode light for at least 1 min	GABAergic and glutamatergic circuits	Liao et al. (2019)