Table 1.

Summary results of MR (Target Gut microbiome on GERD).

Taxa	Exposure	Outcome	Nsnp	Methods	Beta	SE	OR (95%CI)	P value	Heterogeneity		Horizontal pleiotrop
									Cochran’s Q	P value	Egger intercept P	MR-PRESSO P
Phylum	Actinobacteria	GERD	11	Inverse variance weighted	-0.068	0.029	0.93 (0.88-0.99)	0.019	6.835	0.740	0.579	0.78
Phylum	Tenericutes	GERD	3	Inverse variance weighted	0.108	0.048	1.11 (1.01-1.22)	0.024	2.468	0.291	0.364	NA
Family	Clostridiales vadin BB60 group	GERD	10	Inverse variance weighted	-0.049	0.022	0.95 (0.91-0.99)	0.027	4.406	0.882	0.490	0.85
Class	Mollicutes	GERD	5	Inverse variance weighted	0.087	0.042	1.09 (1.01-1.19)	0.037	6.032	0.196	0.745	0.27
Genus	Anaerostipes	GERD	7	Inverse variance weighted	0.083	0.035	1.09 (1.01-1.16)	0.017	5.506	0.480	0.246	0.49
Genus	Lachnospiraceae UCG004	GERD	8	Inverse variance weighted	-0.09	0.042	0.91 (0.84-0.99)	0.026	13.72	0.056	0.789	0.14
Genus	Methanobrevibacter	GERD	4	Inverse variance weighted	-0.047	0.021	0.95 (0.91-0.99)	0.026	0.333	0.953	0.931	0.95