Table 2.

Summary results of bidirectional MR (GERD on target Gut microbiome).

Exposure	Taxa	Outcome	Nsnp	Methods	Beta	SE	OR (95%CI)	P value	Heterogeneity		Horizontal pleiotrop
									Cochran’s Q	P value	Egger intercept P	MR-PRESSO P
GERD	Phylum	Euryarchaeota	64	Inverse variance weighted	-0.197	0.095	0.82 (0.68-0.99)	0.039	49.131	0.899	0.859	0.904
GERD	Family	Christensenellaceae	22	Inverse variance weighted	-0.161	0.080	0.85 (0.73-0.99)	0.045	22.259	0.384	0.052	0.398
GERD	Family	Rikenellaceae	65	Inverse variance weighted	-0.125	0.050	0.88 (0.80-0.97	0.012	81.301	0.071	0.527	0.072
GERD	Genus	Anaerotruncus	65	Inverse variance weighted	-0.101	0.046	0.90 (0.83-0.99	0.028	64.943	0.443	0.708	0.438
GERD	Genus	Christensenellaceae R 7group	65	Inverse variance weighted	-0.109	0.046	0.90 (0.82-0.98)	0.018	56.898	0.723	0.110	0.712
GERD	Genus	Collinsella	65	Inverse variance weighted	0.137	0.049	1.15 (1.04-1.26)	0.005	58.047	0.685	0.325	0.71
GERD	Genus	Eggerthella	65	Inverse variance weighted	0.219	0.082	1.24 (1.06-1.46)	0.007	57.356	0.708	0.147	0.706
GERD	Genus	Eubacterium rectale group	65	Inverse variance weighted	0.111	0.051	1.12 (1.01-1.24)	0.029	82.493	0.059	0.216	0.078
GERD	Genus	Eubacterium ventriosum group	65	Inverse variance weighted	0.111	0.050	1.12 (1.01-1.23)	0.026	70.367	0.273	0.391	0.28
GERD	Genus	Family XIII UCG001	65	Inverse variance weighted	0.109	0.054	1.12 (1.00-1.24)	0.046	70.735	0.262	0.395	0.28
GERD	Genus	Rikenellaceae RC9 gut group	64	Inverse variance weighted	-0.249	0.102	0.78 (0.64-0.95)	0.015	53.945	0.784	0.594	0.768
GERD	Genus	Ruminococcaceae NK4A214 group	65	Inverse variance weighted	-0.118	0.047	0.89 (0.81-0.98)	0.013	50.213	0.895	0.366	0.884
GERD	Genus	Ruminococcaceae UCG005	65	Inverse variance weighted	-0.108	0.046	0.90 (0.82-0.98)	0.019	60.194	0.611	0.689	0.6