Fig. 2.

Effect of starvation on levels of classical autophagy gene products, ER chaperones, enzymes involved in glycolysis, and enzymes involved in the TCA cycle in the liver

(A) Metabolisms in the liver are schematically presented.

(B)–(E) Expression levels of classical autophagy gene products (B), various ER chaperones (C), various enzymes involved in glycolysis (D), and various enzymes involved in the TCA cycle (E) in starved liver are shown relative to those in non-starved liver by Dot-boxplots. Red † and †† denote enzymes whose expression levels were increased more than 1.5-fold and 2-fold, respectively, upon starvation, whereas blue † and †† denote enzymes whose expression levels were decreased more than 1.5-fold and 2-fold, respectively, upon starvation. The blue color of the enzyme PKLR indicates a decrease with significance. The underlining of enzyme DHTKD1 and double-underlining of enzyme DLST denote that they are also involved in amino acid catabolism.