Table 1.
Baseline characteristics of the study participants (n=982)
| Characteristic | Value |
|---|---|
| Cause of liver disease | |
| NAFLD | 497 (50.6) |
| ALD | 85 (8.7) |
| HBV | 129 (13.1) |
| HCV | 122 (12.4) |
| AIH | 38 (3.9) |
| PBC | 44 (4.5) |
| Other | 67 (6.8) |
| Age (year) | 64 (52-72) |
| Sex | |
| Women | 457 (46.5) |
| Men | 525 (53.5) |
| Body mass index (kg/m2) | 25.6 (23.1-28.8) |
| Skin capsular distance (mm) | 19 (15-22) |
| Alcohol abuse | |
| Present | 144 (14.7) |
| Absent | 838 (85.3) |
| Smoking | |
| Present | 235 (23.9) |
| Absent | 747 (76.1) |
| Platelet count (×104/μL) | 20.4 (15.6-24.9) |
| AST (U/L) | 31 (23-48) |
| ALT (U/L) | 35 (20-61) |
| FIB-4 score | 1.04 (0.72-1.55) |
| γ-GT (U/L) | 43 (25-80) |
| Total bilirubin (mg/dL) | 0.8 (0.6-1.0) |
| Albumin (g/dL) | 4.4 (4.1-4.6) |
| ALBI score | -3.00 (-3.19 to -2.75) |
| USAP value (dB/cm/MHz) | 0.70 (0.60-0.78) |
| MRI-derived PDFF (%) | 7.6 (3.7-15.2) |
| Without hepatic steatosis (MRI-derived PDFF <5.2%) | 344 (35.0) |
| With hepatic steatosis (MRI-derived PDFF ≤5.2%) | 638 (65.0) |
| MR elastography value (kPa) | 2.7 (2.1-3.8) |
| Without hepatic fibrosis (MR elastography ≥2.5 kPa) | 484 (49.3) |
| With hepatic fibrosis (MR elastography ≥2.5 kPa) | 498 (50.7) |
Values are presented as number (%) or median (interquartile range).
Steatosis grade: S0, MRI-derived PDFF <5.2%; S1, 5.2≤MRI-derived PDFF<11.3%; S2, 11.3≤MRI-derived PDFF<17.1%; and S3, MRI-derived PDFF ≥17.1% [12].
Fibrosis grade: F0, MR elastography value <2.5kPa; F1, 2.5≤MR elastography value<3.4 kPa; F2, 3.4≤MR elastography value<4.8 kPa; F3, 4.8≤MR elastography value<6.7 kPa; and F4, MR elastography value ≥6.7 kPa [12].
NAFLD, non-alcoholic fatty liver disease; ALD, alcoholic liver disease; HBV, hepatitis B virus; HCV, hepatitis C virus; AIH, autoimmune hepatitis; PBC, primary biliary cholangitis; AST, aspartate aminotransferase; ALT, alanine aminotransferase; FIB-4, fibrosis-4; γ-GT, gamma-glutamyl transpeptidase; ALBI, albumin-bilirubin; USAP, ultrasound attenuation parameter; MRI, magnetic resonance imaging; PDFF, proton density fat fraction.