Table 3.
Background factors of patients with a discrepancy between the UGAP value and MRI-PDFF
| Group A (n=16) | Group B (n=930) | Group C (n=36) | P-value | |
|---|---|---|---|---|
| Age (year) | 65 (48-69) | 64 (52-72) | 68 (55-73) | 0.334 |
| Female sex | 9 (56.2) | 428 (46.0) | 20 (55.6) | 0.390 |
| Alcohol abuse (%) | 5 (31.2) | 133 (14.6) | 6 (16.7) | 0.170 |
| Body mass index (kg/m2) | 27.9 (21.6-29.0) | 25.7 (23.2-29.0) | 22.9 (20.9-24.8) | <0.001 |
| SCD (mm) | 16 (13-19) | 19 (16-22) | 18 (13-20) | 0.009 |
| AST (U/L) | 39 (27-67) | 31 (23-48) | 27 (20-38) | 0.072 |
| ALT (U/L) | 38 (20-81) | 35 (20-61) | 23 (13-37) | 0.004 |
| Platelet count (×104/μL) | 21.8 (14.5-25.2) | 20.5 (15.7-25.1) | 16.7 (12.5-21.4) | 0.006 |
| FIB-4 score | 0.90 (0.73-1.49) | 1.03 (0.71-1.54) | 1.33 (0.85-1.93) | 0.018 |
| Total bilirubin (mg/dL) | 0.8 (0.6-1.1) | 0.8 (0.6-1.0) | 0.8 (0.6-1.1) | 0.489 |
| Albumin (g/dL) | 4.4 (4.2-4.6) | 4.4 (4.1-4.6) | 4.2 (3.8–4.4) | 0.001 |
| ALBI score | -2.95 (-3.24 to -2.85) | -3.00 (-3.20 to -2.76) | -2.81 (-2.96 to -2.41) | 0.001 |
| USAP value (dB/cm/MHz) | 0.55 (0.48-0.65) | 0.70 (0.60-0.79) | 0.62 (0.59-0.67) | <0.001 |
| MRI-derived PDFF (%) | 17.6 (8.7-21.2) | 8.6 (4.9-15.8) | 1.4 (1.1-1.7) | <0.001 |
| MR elastography value (kPa) | 2.3 (2.0-2.9) | 2.7 (2.1-3.8) | 3.3 (2.4-5.2) | 0.011 |
Values are presented as median (interquartile range) or number (%).
Group A (n=16), high MRI-derived PDFF values and low UGAP values; Group B (n=930), concordant MRI-derived PDFF and UGAP values; Group C (n=36), low MRI-derived PDFF and high UGAP values.
USAP, ultrasound attenuation parameter; MRI, magnetic resonance imaging; PDFF, proton density fat fraction; SCD, skin capsular distance; AST, aspartate aminotransferase; ALT, alanine aminotransferase; FIB-4, fibrosis-4; ALBI, albumin-bilirubin.