Table 3.
NP-derived compounds with reported S-ACE2 inhibitory activity sorted by IC50.
| Compound | Source | Reported IC50 (µM) | Reference |
|---|---|---|---|
| Punicalin | Gunnera perpensa | 0.009 | Invernizzi et al. (2022) |
| Punicalagin | Gunnera perpensa | 0.029 | Invernizzi et al. (2022) |
| 4,6-dihydroxyquinoline-2-carboxylic acid | Ephedra sinica | 0.07 | Mei et al. (2021) |
| 4-hydroxy-6-methoxyquinoline-2-carboxylic acid | Ephedra sinica | 0.15 | Mei et al. (2021) |
| 4-hydroxyquinoline-2-carboxylic acid | Ephedra sinica | 0.58 | Mei et al. (2021) |
| Thorectidiol A | Dactylospongia elegans | 1.0 ± 0.7 | Williams et al. (2023) |
| Geraniin | Elaeocarpus sylvestris var. ellipticus and Nepheliuim lappaceum | 4.2 | Kim et al. (2021) |
| Licorice-saponin A3 | Glycyrrhiza uralensis | 8.3 | Yi et al. (2022) |
| Myricetin | Common flavonoid | 10.27 ± 2.32 | Meng et al. (2023) |
| Glycyrrhetinic acid | Glycyrrhiza uralensis | 10.9 | Yi et al. (2022) |
| Quercetin | Common flavonoid | 17.00 ± 3.42 | Meng et al. (2023) |
| Epigallocatechin gallate | Common tannin | 33.9 | Ohishi et al. (2022) |
| Luteolin | Common flavonoid | 610 | Zhu et al. (2023) |