Figure 5.

Treatment transformed the mesenchymal (MES) signature into proneural (PN) features in both cell lines and enhanced the cellular response to oxygen radicals in both cell lines. A. Enrichment analysis of MES features and PN features. Green line indicates where expression correlation values change sign. Red line indicates where the leading-edge set starts. Image bar below indicates the sorted gene expression level. B. Expression levels for select genes in the GBM subtype signature in GSC827. C. Expression pattern of brain tumor related genesets. D, E. Expression pattern and enrichment score (ES) of gene sets related to cellular response to oxygen radicals.