Figure 7.

Genes related to NOTCH signaling, neuron activity, and brain development were promoted by treatment in GSC923. A. Enrichment analysis of NOTCH signaling gene sets in the TS vs. TC contrast in GSC923. Green line indicates where the expression correlation values change sign. Red line indicates where the leading-edge set starts. Image bar below indicates the sorted gene expression level. B. Significantly affected pathways by treatment across both cell lines. C. Expression pattern of gene sets related to brain cell differentiation and development. D. Expression pattern of gene sets related to neuron activities and brain development. E. Expression levels for select genes in the NOTCH signaling gene sets in GSC923. F. Enrichment scores (ES) for gene sets related to the MYC signaling pathway.