Figure 7.

CXCL12-secreting TAMs regulate PD-L1⁺ Bregs through the CXCL12/CXCR4 axis. A. Representative figures for multiple-color staining of CD38, IgA, PD-L1, CXCR4, CD163, and CXCL12 expression in human HCC and adjacent samples. B. Dot plots showing the proportions of four types of cells. Different colors represent different cells. C. Liner correlation studies were performed for CXCR4 expression vs PD-L1 expression in PD-L⁺ CXCR4⁺ B cells and B cells in HCC and adjacent tissues. D. Linear correlation studies were performed between a count of TAMs and CXCL12⁺ TAMs in clinical samples with a count of B cells, PD-L1⁺ Breg cells, and PD-L1⁺ CXCR4⁺ B cells.