Table 2.
Serological markers and other non-invasive tests for NAFLD-Related Fibrosis. Data from cross-sectional studies.
| markers | N Training set/Validation set |
AUC |
Diagnostic accuracy | |
|---|---|---|---|---|
| Training set | Validation set | |||
| 3D-MRE [66] | 100 | NR | 0.981 | at 60 Hz: AUC = 0.927 Cut-off = 3.40 kPa, PPV = 72.2%, NPV = 97.5% at 40 Hz: AUC = 0.981 Cut-off = 2.43 kPa, PPV = 72.2 %, NPV = 1.0% |
| 2D-MRE [66] | 100 | NR | 0.921 | at 60 Hz: Cut-off = 3.80 kPa, PPV = 81.2%, NPV = 97.6% |
| Fibro MRI [69] | 39/87 | 0.940 | 0.850 | Training set: cut-off = 0.5, PPV = 77%, NPV = 86% Validation set: cut-off = 0.5, PPV = 67%, NPV = 87%. |
| MRE [64] | 104 | NR | 0.820 | F2: AUC = 0.89, F3: AUC = 0.87, F4: AUC = 0.87 |
| RP11‐128N14.5 lncRNA [83] | 88/50 | 0.706 | 0.694 | Training set: sensitivity = 73.7%, specificity = 70.4% Validation set: sensitivity = 78.3%, specificity = 63%, |
| BNIP3L mRNAs [83] | 88/50 | 0.676 | 0.686 | Training set: sensitivity = 57.9%, specificity = 81.5% Validation set: sensitivity = 51.9%, specificity = 91.3%, |
| Complement component C7 [88] | 19 | 1 | NR | NR |
| α-2-macroglobulin [88] | 19 | 0.870 | NR | NR |
| Complement component C8 γ chain [88] | 19 | 0.800 | NR | NR |
| Fibulin-1 [88] | 19 | 0.790 | NR | NR |
| α-1-antichymotrypsin [88] | 19 | 0.800 | NR | NR |
| the FM-fibro LSM index [60] | 249 | 0.943 | 0.941 | cut-off = 7.201, PPV = 73.5%, NPV = 94.6% |
| top 10 metabolite panel [78] | 156/59 | 0.940 | 0.840 | Sensitivity = 90%, specificity = 79% |
| IGF-1 + ferritin + INR [82] | 225 | NR | 0.810 | PPV = 98%, NPV = 71% |
| TGFB2/TGFB2‐OT1 Test [83] |
88/50 | 0.797 | 0.786 | Training set: sensitivity = 65%, specificity = 81.3% Validation set: sensitivity = 62.5%, specificity = 94.4% |
| TGFB2/TGFB2‐OT1 + FIB‐4 [83] | 88/50 | 0.891 | 0.889 | Training set: sensitivity = 80%, specificity = 87.5% Validation set: sensitivity = 87.5%, specificity = 83.3% |
| 7 eicosanoids panel [35] | 426 | 0.740 | NR | NR |
3D-MRE: Three-dimensional MRE; 2D-MRE: two-dimensional MRE; Fibro MRI: the diagnostic accuracy of significant fibrosis prediction; MRE; magnetic resonance elastography; the FM-fibro LSM index: combination of the FM-fibro index and LSM; top 10 metabolite panel: the top 10 serum metabolites including 5alpha-androstan-3beta monosulfate, pregnanediol-3-glucuronide, androsterone sulfate, epiandrosterone sulfate, palmitoleate, dehydroisoandrosterone sulfate, 5alpha-androstan-3beta disulfate, glycocholate, taurine and fucose; 7 eicosanoids panel: 5-HETE, 7,17-DHDPA, adrenic acid, arachidonic acid, eicosapentaenoic acid, 16-HDOHE, and 9-HODE.