Table 2. Clinicopathologic and molecular features of CLDN18.2-positive or negative (cut-off: 2+, 70%) GC patients.
| Characteristics | n (%) | P | |
| CLDN18.2-neg | CLDN18.2-pos | ||
| CLDN18.2, claudin 18 isoform 2; GC, gastric cancer; EGJ, gastroesophageal junction; HER2, epidermal growth factor receptor 2; IHC, immunohistochemistry; FISH, fluorescence in situ hybridization; amp, amplification; PD-L1, programmed death-ligand 1; CPS, combined positive score; EBV, Epstein-Barr virus; dMMR, mismatch repair-deficient; pMMR, mismatch repair-proficient; TMB, tumor mutational burden; muts, mutations; pos, positive; neg, negative. | |||
| Total | 274 (51.1) | 262 (48.9) | |
| Age (year) | |||
| <60 | 161 (58.8) | 203 (78.1) | <0.001 |
| ≥60 | 113 (41.2) | 57 (21.9) | |
| Sex | |||
| Female | 73 (26.8) | 125 (47.7) | <0.001 |
| Male | 199 (73.2) | 137 (52.3) | |
| Histopathology | |||
| EGJ | 76 (28.1) | 37 (14.6) | <0.001 |
| Non-EGJ | 194 (71.9) | 217 (85.4) | |
| Lauren | |||
| Diffuse | 74 (34.6) | 115 (51.6) | <0.001 |
| Intestinal | 94 (43.9) | 54 (24.2) | |
| Mixed | 46 (21.5) | 54 (24.2) | |
| Differentiation | |||
| High | 2 (0.8) | 3 (1.2) | 0.023 |
| Moderate | 61 (24.2) | 36 (14.6) | |
| Poor | 189 (75.0) | 208 (84.2) | |
| Metastasis site | |||
| Liver | 91 (29.0) | 53 (16.6) | <0.001 |
| Lung | 33 (10.5) | 18 (5.6) | 0.024 |
| Peritoneum | 150 (47.8) | 171 (53.4) | 0.154 |
| Uterine adnexa | 26 (8.3) | 64 (20.0) | <0.001 |
| Lymph node | 14 (4.5) | 14 (4.4) | 0.959 |
| HER2 status | |||
| Negative | 215 (85.0) | 233 (94.0) | 0.001 |
| Positive | 38 (15.0) | 15 (6.0) | |
| IHC 2+ FISH amp |
12 (31.60) | 5 (33.3) | 0.902 |
| IHC 3+ | 26 (68.40) | 10 (66.7) | |
| PD-L1 status | |||
| CPS<1 | 128 (51.8) | 157 (65.1) | 0.003 |
| CPS≥1 | 119 (48.2) | 84 (34.9) | |
| CPS<5 | 168 (68.0) | 189 (78.4) | 0.009 |
| CPS≥5 | 79 (32.0) | 52 (21.6) | |
| CPS<10 | 191 (77.6) | 210 (87.1) | 0.006 |
| CPS≥10 | 55 (22.4) | 31 (12.9) | |
| EBV status | |||
| Negative | 203 (99.5) | 200 (97.6) | 0.101 |
| Positive | 1 (0.5) | 5 (2.4) | |
| MMR status | |||
| dMMR | 3 (0.9) | 4 (1.7) | 0.420 |
| pMMR | 230 (99.1) | 231 (98.3) | |
| TMB (muts/Mb) | |||
| TMB<10 | 46 (78.0) | 50 (83.3) | 0.458 |
| TMB≥10 | 13 (22.0) | 10 (16.7) | |