Table S6. ORR/DCR with ICIs according to CLDN18.2 expression.

Positivity	n (%)
ORR, objective response rate; DCR, disease control rate; ICI, immune checkpoint inhibitor; CLDN18.2, claudin 18 isoform 2.
ORR (total)
CLDN18.2 ≥2+, 40%	16 (30.7)
CLDN18.2 <2+, 40%	14 (45.2)
DCR (total)
CLDN18.2 ≥2+, 40%	38 (73.0)
CLDN18.2 <2+, 40%	23 (74.2)
ORR (1st line)
CLDN18.2 ≥2+, 40%	14 (42.4)
CLDN18.2 <2+, 40%	8 (57.1)
DCR (1st line)
CLDN18.2 ≥2+, 40%	28 (84.8)
CLDN18.2 <2+, 40%	13 (92.9)
ORR (≥2nd line)
CLDN18.2 ≥2+, 40%	2 (10.5)
CLDN18.2 <2+, 40%	6 (35.3)
DCR (≥2nd line)
CLDN18.2 ≥2+, 40%	10 (52.6)
CLDN18.2 <2+, 40%	10 (58.8)
ORR (total)
CLDN18.2 ≥2+, 70%	15 (35.7)
CLDN18.2 <2+, 70%	15 (36.6)
DCR (total)
CLDN18.2 ≥2+, 70%	31 (73.8)
CLDN18.2 <2+, 70%	30 (73.2)
ORR (1st line)
CLDN18.2 ≥2+, 70%	13 (52.0)
CLDN18.2 <2+, 70%	9 (42.9)
DCR (1st line)
CLDN18.2 ≥2+, 70%	22 (88.0)
CLDN18.2 <2+, 70%	19 (90.5)
ORR (≥2nd line)
CLDN18.2 ≥2+, 70%	2 (12.5)
CLDN18.2 <2+, 70%	6 (30.0)
DCR (≥2nd line)
CLDN18.2 ≥2+, 70%	9 (56.3)
CLDN18.2 <2+, 70%	11 (55.0)