Figure S3.

Correlations analysis of co-occurrence genes in GEPNEC and LNEC. (A) Co-occurrence and mutual exclusiveness of gene alteration pattern in GEPNEC patients; (B) Co-occurrence and mutual exclusiveness of gene alteration pattern in LNEC patients. GEPNEC, gastroenteropancreatic neuroendocrine carcinoma; LNEC, lung NEC. Co-occurring mutations are indicated by green squares and mutually exclusive mutations between gene pairs in purple. The color intensity is proportionate the –log10 (P-value). P values were determined using Fisher’s exact test.