Table S4. Alterations frequency differences between SCNEC and LCNEC.

Gene	% (n/N)		OR (95% CI)	P
SCNEC, small-cell neuroendocrine carcinoma; LCNEC, large-cell neuroendocrine carcinoma; GEPSCNEC, gastroenteropancreatic SCNEC; GEPLCNEC, gastroenteropancreatic LCNEC; OR, odds ratio; 95% CI, 95% confidence interval; Inf and −Inf, infinitive and −infinitive.
	SCNEC vs. LCNEC
KEAP1 (mutation)	2.2 (2/93)	16.4 (10/61)	9.20 (1.86−89.54)	0.001
FANCM (mutation)	0 (0/93)	8.2 (5/61)	Inf (1.52−Inf)	0.008
TP53 (mutation)	66.7 (62/93)	83.6 (51/61)	2.83 (1.23−7.03)	0.011
CDH1 (mutation)	0 (0/93)	6.6 (4/61)	Inf (1.08−Inf)	0.021
KIT (mutation)	0 (0/93)	6.6 (4/61)	Inf (1.08−Inf)	0.021
RB1 (mutation)	51.6 (48/93)	31.1 (19/61)	0.47 (0.23−0.96)	0.025
CTNNB1 (mutation)	7.5 (7/93)	18.0 (11/61)	2.82 (0.93−9.13)	0.071
ERCC5 (mutation)	0 (0/93)	4.9 (3/61)	Inf (0.67−Inf)	0.055
FGFR1 (mutation)	0 (0/93)	4.9 (3/61)	Inf (0.67−Inf)	0.055
FLT1 (mutation)	0 (0/93)	4.9 (3/61)	Inf (0.67−Inf)	0.055
RHOA (mutation)	0 (0/93)	4.9 (3/61)	Inf (0.67−Inf)	0.055
ERBB4 (mutation)	2.2 (2/93)	9.8 (6/61)	5.14 (0.88−53.75)	0.058
NOTCH1 (mutation)	15.1 (14/93)	4.9 (3/61)	0.31 (0.05−1.18)	0.065
ATR (mutation)	8.6 (8/93)	1.6 (1/61)	0.15 (0−1.08)	0.088
	GEPSCNEC vs. GEPLCNEC
CDH1 (mutation)	0 (0/55)	9.3 (4/43)	Inf (0.87−Inf)	0.034
FANCM (mutation)	0 (0/55)	9.3 (4/43)	Inf (0.87−Inf)	0.034
ATR (mutation)	9.1 (5/55)	0 (0/43)	0 (0−1.35)	0.065
TP53 (mutation)	76.4 (42/55)	90.7 (39/43)	0.84 (0.23−1.12)	0.063