Table S5. Alterations frequency differences between pure NEC and MiNEN.

Gene	Pure NEC [% (n/N)]	MiNEN [% (n/N)]	OR (95% CI)	P
NEC, neuroendocrine carcinoma; MiNEN, mixed neuroendocrine-non-neuroendocrine neoplasia; OR, odds ratio; 95% CI, 95% confidence interval.
KRAS (mutation)	20.7 (17/82)	23.5 (4/17)	1.13 (0.30−5.13)	0.945
APC (mutation)	23.2 (19/82)	29.4 (5/17)	1.26 (0.20−2.97)	0.813
RB1 (mutation)	41.5 (34/82)	23.5 (4/17)	0.63 (0.63−10.4)	0.166
TP53 (mutation)	84.1 (69/82)	82.4 (14/17)	0.95 (0.18−4.96)	0.858