Table S6. Alterations frequency differences in GEPNEC and adenocarcinoma.

Gene	% (n/N)		OR (95% CI)	P
GEPNEC, gastroenteropancreatic neuroendocrine carcinoma; GNEC, gastric NEC; STAD, stomach adenocarcinoma; CRNEC, colorectal NEC; COREAD, colorectal adenocarcinoma; PNEC, pancreas NEC; PAC, pancreatic adenocarcinoma.
	GNEC vs. STAD
ARID1A (mutation)	0 (0/32)	34.6 (9/26)	0 (0−0.21)	<0.001
TP53 (mutation)	84.4 (27/32)	57.7 (15/26)	4.20 (1.23−15.44)	0.014
PI3KCA (mutation)	0 (0/32)	15.4 (4/26)	0.01 (0−0.77)	0.016
LRP1B (mutation)	12.5 (4/32)	38.5 (10/26)	0.23 (0.06−0.84)	0.020
RB1 (mutation)	25.0 (8/32)	3.8 (1/26)	8.16 (1.08−369.00)	0.033
	CRNEC vs. COREAD
RB1 (mutation)	38.9 (7/18)	10.7 (6/56)	0.19 (0.05−0.67)	<0.001
	PNEC vs. PAC
KRAS (mutation)	16.7 (2/12)	75.0 (9/12)	0.10 (0.01−0.84)	0.034