Table 4. Tumor response per RECIST v1.1.
| Best overall response | n (%) | ||||||||
| 50 mg QD (n=3) |
100 mg QD (n=3) |
200 mg QD (n=3) |
300 mg QD (n=3) |
400 mg QD (n=3) |
500 mg QD (n=3) |
600 mg QD (n=4) |
300 mg BID (n=6) |
All patients (n=28) |
|
| RECIST, response evaluation criteria in solid tumors; DCR, disease control rate. *, Patient no identifiable lesions on imaging but more than 6 years on Hemay022 without progression. | |||||||||
| Complete response | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 0 (0) | 1 (33.3) | 0 (0) | 0 (0) | 1 (3.6) |
| Partial response | 0 (0) | 0 (0) | 0 (0) | 1 (33.3) | 0 (0) | 0 (0) | 0 (0) | 2 (33.3) | 3 (10.7) |
| Stable disease | 0 (0) | 2 (66.7) | 2 (66.7) | 1 (33.3) | 0 (0) | 0 (0) | 2 (50.0) | 2 (33.3) | 9 (32.1) |
| Not available | / | / | / | / | / | 1 (33.3)* | / | / | 1 (3.6) |
| DCR [% (95% CI)] | 0 | 66.7 (13.3−100) | 66.7 (13.3−100) | 66.7 (13.3−100) | 0 | 33.3 (0−86.7) | 50.0 (1.0−99.0) | 66.7 (28.9−100) | 46.4 (28.0−64.9) |