Table 3B.
Multivariate cox regression of all patients and variables effect on progression-free survival and overall survival.
| Variable | PFS | OS | ||
|---|---|---|---|---|
| HR (95%CI) | P | HR (95%CI) | P | |
| Age (≥65 vs <65) | 1.34(0.91-2.18) | 0.36 | 1.28(0.63-2.11) | 0.31 |
| ECOG (≥2 vs 0-1) | 2.01(1.99-3.13) | 0.02 | 2.58(1.38-3.54) | <0.01 |
| BRAF status (BRAF wt vs BRAF mutated) | 0.73(0.41-1.30) | 0.29 | 0.73(0.51-1.76) | 0.36 |
|
Number of metastases during first-line treatment
(≥2 vs 1) |
2.09(0.98-4.41) | 0.09 | – | – |
|
Brain metastases
(Yes vs No) |
2.14(1.28-3.56) | 0.02 | 1.78(1.25-3.33) | <0.01 |
|
Liver metastases
(Yes vs No) |
1.34(0.63-2.85) | 0.45 | 1.62(0.92-2.83) | 0.26 |
|
LDH level
(Normal vs Elevated) |
0.62(0.28-0.89) | 0.04 | 0.55(0.37-0.88) | 0.03 |