Figure 6.

Topology map of altered metabolic pathways, which describes the impact of metabolites selected from a comparative t-test (p-value < 0.05), adjusted for multiple hypotheses testing by false discovery rate (FDR). The top ten altered metabolic pathways in the cancer cachexia group are 1. aminoacyl tRNA biosynthesis, 2. valine, leucine and isoleucine metabolism, 3. glutathione metabolism, 4. valine, leucine and isoleucine degradation, 5. arginine biosynthesis, 6. alanine, aspartate and glutamate metabolism, 7. phenylalanine, tyrosine, and tryptophan metabolism, 8. glyoxylate and dicarboxylate metabolism, 9. glycine, serine, and threonine metabolism, and 10. arginine and proline metabolism.