TABLE 3.

Multivariable analysis of all patients with nonmetastatic resected cardia gastric cancer treated with perioperative chemotherapy, postoperative chemoradiation therapy, and postoperative chemotherapy including subgroup analysis of optimally treated cohort.

		All patient analysis			Optimally treated cohort
Covariate	Level	Hazard ratio (95% CI)	HR p value	Overall p value	Hazard ratio (95% CI)	HR p value	Overall p value
Treatment group: weighted against POC	Perioperative chemotherapy	1.04 (0.86–1.26)	0.701	0.680	1.01 (0.77–1.33)	0.919	0.993
	Postoperative chemoradiation	0.97 (0.85–1.10)	0.607		1.00 (0.78–1.29)	0.992
	Postoperative chemotherapy	-	-		-	-
Treatment group: weighted against PEC	Postoperative chemoradiation	0.93 (0.78–1.11)	0.416	0.680	0.99 (0.77–1.26)	0.918	0.993
	Postoperative chemotherapy	0.96 (0.80–1.17)	0.701		0.99 (0.75–1.30)	0.919
	Perioperative chemotherapy	-	-		-	-
Age	Above median	1.46 (1.31–1.63)	<0.001	<0.001	-	-	-
	Below median	-	-
Median income quartiles 2008–2012	$38 000–$47 999 $48 000–$62 999	0.91 (0.76–1.09) 0.84 (0.70–1.00)	0.331 0.052	0.038	-	-	-
	≥$63000	0.79 (0.67–0.94)	0.009
	<$38 000	-	-
Primary payor	Private/not insured	-	-	-	0.73 (0.60–0.90)	0.003	0.003
	Medicare/Medicaid/other government	-	-		-	-
Charlson-Deyo score	1+	1.14 (1.01–1.29)	0.028	0.028	-	-	-
	0	-	-
Year of diagnosis	2011–2016	0.87 (0.77–0.98)	0.024	0.024	-	-	-
	2006–2010	-	-
Grade	Poorly differentiated/undifferentiated	1.21 (1.07–1.36)	0.002	0.002	-	-	-
	Well/moderately differentiated	-	-
Regional lymph nodes positive	Positive	1.90 (1.62–2.24)	<0.001	<0.001	2.22 (1.67–2.95)	<0.001	<0.001
	Negative	-	-		-	-
Surgical margins status	Positive	2.02 (1.76–2.32)	<0.001	<0.001	-	-	-
	Negative	-	-

Note: Values in bold indicate statistical significance.