Table 1.
Number of DMRs and DMPs identified by different approaches
| dmrff | gbdmr 1 | EWAS | |||
|---|---|---|---|---|---|
| Analysis index | DMPs | DMRs | DMPs | DMRs | DMPs |
| 1. IOW male vs. female2 | 2085 | 900 (2418) | 1884 | 1114 (3727) | 3435 |
| 2. IOW male vs. female3 | 468 | 148 (391) | 423 | 649 (2352) | 697 |
| 3. IOW male vs. female4 | 1050 | 418 (1163) | 1092 | 457 (1494) | 1664 |
| 4. IOW male vs. female5 | 4226 | 1986 (5314) | 4300 | 1814 (5798) | 7800 |
| 5. IOW gestational age5 | 908 | 333 (907) | 996 | 352 (1120) | 1360 |
| 6. IOW birth weight5 | 210 | 78 (220) | 219 | 138 (547) | 303 |
| 7. GSE59065 male vs. female6 | 946 | 345 (1008) | 1010 | 448 (2224) | 1304 |
| 8. GSE59065 young vs. old6 | 20453 | 12376 (37651) | 22814 | 9252 (27757) | 42126 |
| 9. GSE87571 male vs. female7 | 3381 | 1861 (5394) | 3575 | 1613 (5611) | 6710 |
| 10. GSE87571 age7 | 72070 | 28586 (87185) | 101188 | 11741 (31409) | 133507 |
Using data in the IOW cohort and GSE datasets. DMPs: differential methylated CpG sites; DMRs: differential methylated regions that contain more than one CpG site. The number of DMR CpGs is included in the parentheses
1 The adjacent correlation threshold used for gbdmr is 0.5. 2 IOW dataset age 26. 3 IOW dataset age 18. 4 IOW dataset age 10. 5 IOW dataset age at birth. Gestational age is used to describe how far along the pregnancy is. It is measured in weeks
6 Age-related profiling of DNA methylation in CD8+ T cells and age is recorded as a binary variable
7 Continuous Aging of the Human DNA Methylome Throughout the Human Lifespan Dataset