Table 1.
Urine albumin and kidney weight parameters at the end-points of two in vivo experiments
| Parameters | 10 weeks | 18 weeks | ||||
|---|---|---|---|---|---|---|
| Non-DM1 | DM + NS1 | DM + MSC1 | Non-DM2 | DM + NS2 | DM + MSC2 | |
| UMA (mg/L) | 3.580 ± 0.505 | 6.520 ± 1.023 | 5.460 ± 1.103 | 3.872 ± 0.778 | 4.961 ± 1.375 | 2.036 ± 0.438 |
| Ucr (mmol/L) | 5.152 ± 0.837 | 1.028 ± 0.178* | 1.270 ± 0.267* | 2.707 ± 0.171 | 0.499 ± 0.081* | 0.277 ± 0.027* |
| uACR (mg/g) | 8.080 ± 0.836 | 74.520 ± 7.334* | 47.740 ± 3.616*# | 12.860 ± 1.994 | 88.402 ± 3.240* | 70.340 ± 17.470*# |
| KW (g) | 0.200 ± 0.009 | 0.156 ± 0.007* | 0.160 ± 0.006* | 0.178 ± 0.007 | 0.147 ± 0.003* | 0.165 ± 0.011 |
| KI (mg/g) | 6.189 ± 0.143 | 7.408 ± 0.217* | 7.013 ± 0.240* | 6.456 ± 0.196 | 8.007 ± 0.429* | 8.045 ± 0.311* |
Non-DM1 = Nondiabetic mice analyzed 10 weeks after initiation of the experiments; DM + NS1 = Diabetic mice injected with normal saline and analyzed 10 weeks after induction of diabetes; DM + MSC1: Diabetic mice injected with hUC-MSCs and analyzed 10 weeks after induction of diabetes; Non-DM2 = Nondiabetic mice analyzed 18 weeks after initiation of the experiments; DM + NS2 = Diabetic mice injected with normal saline and analyzed 18 weeks after induction of diabetes; DM + MSC2: Diabetic mice injected with hUC-MSCs and analyzed 18 weeks after induction of diabetes; UMA = Urine microalbumin concentration; Ucr = Urine creatinine concentration; uACR = Urine albumin creatinine ratio; KW = Kidney weight; KI, Kidney index. Data are presented as the mean ± SEM
* = p < 0.05 versus Non-DM group, # = p < 0.05 versus DM + NS group