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. 2024 Mar 5;22:241. doi: 10.1186/s12967-024-04973-7

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© The Author(s) 2024

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 1 — Clinical timeline and tissue specimens. A, Melanoma course, occurrence of irAEs, and specimens collected from patient MA-6. The top timeline shows tissue collections; the middle timeline shows melanoma status and systemic therapies (not including focal radiotherapy); the bottom timeline shows the irAEs and their pharmacologic management. Not included in the bottom timeline is the onset of grade 2 adrenal insufficiency of clinically unclear etiology, treated with hydrocortisone replacement. IFN-a, adjuvant interferon alfa. B, Tissue specimens from patient MA-6 that were used in this study. Biopsy and surgical specimens were collected pre-mortem, others were collected at autopsy. Green boxes, assays performed; black boxes, assays not done. IHC immunohistochemistry; met, metastasis, qRT-PCR quantitative real-time reverse transcription polymerase chain reaction, TCRseq T-cell receptor sequencing