TABLE 2.
Activity of gepotidacin, ciprofloxacin, and levofloxacin against attenuated B. anthracis single-step gyrase mutantsc
| Strain | Amino acid change | Frequency of isolationb | Gepotidacin | Ciprofloxacin | Levofloxacin |
|---|---|---|---|---|---|
| MIC | MIC | MIC | |||
| (μg/mL) | (μg/mL) | (μg/mL) | |||
| Parent ΔANRa | NA | NA | 1 | 0.03 | 0.06 |
| S1-1^ | S85L | 80% | 2 | 1 | 0.25 |
| S1-2^ | E89K | 20% | 2 | 1 | 0.25 |
a
Plasmid-cured B. anthracis Ames strain.
b
Laboratory-generated mutants; the frequency of isolation is from the original publication (30).
c
MIC: minimum inhibitory concentration; NA: not applicable.