TABLE 3.

Aerosol exposure range, time to trigger, time to treatment, bacteremia onset, and challenge dose^b,c

Treatment	LD50 exposure average (range)	Time to triggera (hours post challenge) median (95%)	Time to onset of bacteremia (hours) median (95%)	% Bacteremic PTT	Time to SIBT median (95%)
Gepotidacin	180 (106–257)	28.4 (24.5–35.4)	24.7 (22.6–28.6)	100	29.3 (25.2–30.6)
Saline	212 (157–258)	28.3 (23.3–38.3)	25.5 (23.0–31.3)	100	27.9 (23.9–33.4)

^a Trigger = positive PA-ECL.

^b No statistical difference between the LD₅₀ exposure, time from trigger to treatment, bacteremia onset, or challenge dose (two-tailed t-test).

^c LD₅₀, lethal dose; PTT = prior to treatment; SIBT = significant increase in body temperature.