TABLE 4.

Geometric means and range for positive quantitative B. anthracis bacteremia (log₁₀ CFU/mL)^a,c,d

	Gepotidacin		Saline
Time point	No. of culture-positive/total no. of animals	Geometric mean (range)	No. of culture positive/total no. of animals	Geometric mean (range)
24 h PC	6/11	2.63 (<2.40, 3.04)	3/6	2.88 (<2.40, 3.52)
30 h PC	6/7	2.78 (<2.40, 3.06)	4/4	2.62 (<2.40, 3.17)
36 h PC	3/3	2.66 (<2.40, 3.11)	2/2	2.83 (2.67, 3.0)
42 h PC	1/1	<2.40 (--)	0/0	--(--)
PTT	9/9b	3.04 (<2.40, 3.82)	6/6	3.30 (<2.40, 5.12)
24 PTI	9/11	3.70 (<2.40, 4.64)	5/5	4.56 (4.05, 6.13)
Day 7 PC	0/10	--(--)	0/0	--(--)
Day 14 PC	0/10	--(--)	0/0	--(--)
Day 28 PC	0/10	--(--)	0/0	--(--)
Terminal	1/1	3.18 (--)	6/6	8.07 (6.15, 8.78)

^a Parameter was log₁₀-transformed for the analysis.

^b Blood samples were not available for two animals that were positive at time points prior to PTT.

^c -- Samples were not collected for this group at this time point, or all results were below the LLOQ, or there was a single observation for this group at this time point.

^d LLOQ = 2.40 log10 CFU/mL; LLOQ = lower limit of quantification; PC = post-challenge; PTT = prior to treatment ; PT1 = post first treatment.