TABLE 5.

Geometric means and range for positive B. anthracis tissue burden (log₁₀ CFU/g)^a,c,d

	Gepotidacin		Saline
Tissue	No. of culture-positive/total no. of animals	Geometric mean (range)	No. of culture-positive/total no. of animals	Geometric mean (range)
Heart	1/11	<3.40 (--)	6/6	7.54 (<3.40, 7.94)
Brain	1/11	6.84 (--)	6/6	6.64 (3.68, 8.27)
Lung	2/11b	<3.40 (<3.40)	6/6	8.74 (4.49, 9.03)
Kidney	1/11	3.44 (--)	6/6	6.34 (<3.40, 8.15)
Spleen	2/10b	3.89 (<3.40, 4.22)	6/6	8.31 (6.92, 9.20)
Mediastinal lymph node	1/11	3.44 (--)	6/6	7.75 (7.02, 8.48)

^a Parameter was log₁₀-transformed for the analysis. LLOQ = 3.40 log₁₀ CFU/mL (triple plating was used for counts and <25 colonies were seen on two of three plates).

^b Includes a gepotidacin-treated survivor that was culture-positive at the study end.

^c -- Range of counts could not be determined since there was only one positive observation for this group at this time point or results were the same.

^d CFU, colony-forming units; LLOQ, lower limit of quantification.