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The drug resistance of AZ5385-passaged HRV-2. (A) The virus was subjected 11 consecutive passages in the presence of 3.5 µM AZ5385, and the sensitivity of original, control passage 11 (p.11), AZ5385 p.11, and AZ5385 p.3, 6, and 7 viruses was examined as described in Fig. 1A. (B) Schematic representation of emergence of specific mutations in AZ5385-passaged HRV-2.
