TABLE 1.
Inhibitory activity of ANT3310 and other SBL inhibitorsb
| Enzyme IC50 (nM) | ||||||
|---|---|---|---|---|---|---|
| KPC-2 | OXA-48 | OXA-23 | OXA-24/40 | OXA-51 | OXA-58 | |
ANT3310a
|
19.5 | 179 | 32.6 | 602 | 542 | 8 |
Avia
|
7.5 | 252 | >3,000 | >10,000 | >10,000 | >10,000 |
Rela
|
17.1 | >3,000 | >3,000 | >10,000 | >10,000 | >10,000 |
Zida
|
38.9 | >3,000 | >3,000 | >10,000 | >10,000 | >10,000 |
Naca
|
27.2 | >3,000 | >3,000 | >10,000 | >10,000 | >10,000 |
Dura
|
5.3 | 3.4 | 346.6 | 208 | 4,303 | 11 |
Tan
|
15.8 | 1,562 | >3,000 | >10,000 | >10,000 | >10,000 |
Vab
|
102 | >3,000 | >3,000 | >1,0000 | >1,0000 | >10,000 |
a
DBO.
b
Avi, avibactam; Rel, relebactam; Zid, zidebactam; Nac, nacubactam; Dur, durlobactam; Tan, taniborbactam; Vab, vaborbactam.