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. 2023 Sep 26;30(3):e14456. doi: 10.1111/cns.14456

FIGURE 4.

FIGURE 4

NPGE treatment attenuated ferroptosis–related neuroinflammation after I/R injury. (A) Western blotting analysis of NLRP3 and HMGB1 in the ischemic penumbra tissue after CIRI, n = 6. (B–D) The levels of IL–1β, IL–6 and TNF–α in the ischemic penumbra tissue, n = 5. (E) Western blotting analysis of NLRP3 and HMGB1 in HT22 cells after OGD/R, n = 3. (F–H) The levels of IL–1β, IL–6 and TNF–α in HT22 cells after OGD/R, n = 9. (I, J) The levels of Fe2+ and GSH in erastin‐exposed HT22 cells, n = 9. (K–M) The levels of IL–1β, IL–6 and TNF–α in erastin‐exposed HT22 cells, n = 9. (N) Western blot analysis of SLC7A11, GPX4, NLRP3 and HMGB1 in erastin‐exposed HT22 cells, n = 3. *p < 0.05, **p < 0.01, ***p < 0.001.