FIG. 10.

DNA-PK_CS-deficient and wild-type cells display similar patterns of chromosome condensation in the presence of ICRF-193. AA8 and V-3 cells were synchronized at late S/G₂ phase and then treated with 0, 0.01, 0.02, 0.05, 0.1, and 1 μg of ICRF-193 per ml, 80 ng of nocodazole per ml, and 2 mM caffeine for 5 h. Metaphase chromosomes were prepared as described in Materials and Methods. Representative images of AA8 and V-3 cells are shown.