Fig. 3.
The prediction of risk for major depression (MD), obsessive-compulsive disorder (OCD), bipolar disorder (BD), schizophrenia (SZ), anorexia nervosa (AN), alcohol use disorder (AUD), and drug use disorder (DUD) from three variables in a multivariate cox regression: (i) average school grades at age 17 (grades), (ii) the deviation of those grades from family-genetic expectations for educational attainment (deviation 1), and (ii) the changes in grades from ages 17 to 19 (deviation 2). Family-genetic expectations educational attainment was calculated from first to fifth degree relatives using the familial-genetic potential for educational attainment (FGPEA), detailed in the Appendix Table 2. See Methods for further details.